Brassica oleracea Genome Database
Caffeine metabolism
| Pathway Node | Enzyme Sequence |
|---|---|
| 7-methylxanthosine synthase(K12729) | MELQEVLRMNGGEGDTSYAKNSAYNQLVLAKVKPVLEQCVRELLRANLPNINKCIKVADL GCASGPNTLLTVRDIVQSIDKVGQEKKNELERPTIQIFLNDLFPNDFNSVFKLLPSFYRK LEKENGRKIGSCLIGAMPGSFYSRLFPEESMHFLHSCYCLQWLSQVPSGLVTELGIGTNK GSIYSSKASRLPVQKAYLDQFTKDFTTFLRIHSEELFSHGRMLLTCICKGVELDARNAID LLEMAINDLVVEGHLEEEKLDSFNLPVYIPSAEEVKCIVEEEGSFEILYLETFKVLYDAG FSIDDEHIKAEYVASSVRAVYEPILASHFGEAIIPDIFHRFAKHAAKVLPLGKGFYNNLI ISLAKKPEKSDM |
| theobromine synthase(K12730) | MELQEVLHMNEGEGDTSYAKNASYNLALAKVKPFLEQCIRELLRANLPNINKCIKVADLG CASGPNTLLTVRDIVQSIDKVGQEEKNELERPTIQIFLNDLFQNDFNSVFKLLPSFYRKL EKENGRKIGSCLISAMPGSFYGRLFPEESMHFLHSCYSVHWLSQVPSGLVIELGIGANKG SIYSSKGCRPPVQKAYLDQFTKDFTTFLRIHSKELFSRGRMLLTCICKVDEFDEPNPLDL LDMAINDLIVEGLLEEEKLDSFNIPFFTPSAEEVKCIVEEEGSCEILYLETFKAHYDAAF SIDDDYPVRSHEQIKAEYVASLIRSVYEPILASHFGEAIMPDLFHRLAKHAAKVLHMGKG CYNNLIISLAKKPEKSDV |
| caffeine synthase(K12731) | MELQEVLHMNGGEGDTSYAKNSFYNLFLIRVKPILEQCIQELLRANLPNINKCIKVADLG CASGPNTLLTVRDIVQSIDKVGQEKKNELERPTIQIFLNDLFQNDFNSVFKSLPSFYRKL EKENGRKIGSCLIGAMPGSFYGRLFPEESMHFLHSCYCLHWLSQVPSGLVTELGISANKG CIYSSKASRPPIQKAYLDQFTKDFTTFLRIHSEELISRGRMLLTWICKEDEFENPNSIDL LEMSINDLVIEGHLEEEKLDSFNVPIYAPSTEEVKCIVEEEGSFEILYLETFKVPYDAGF SIDDDYQGRSHSPVSCDEHARAAHVASVVRSIFEPIVASHFGEAIMPDLSHRIAKNAAKV LRSGKGFYDSLIISLAKKPEKSDV |
| methylxanthine N1-demethylase(K21722) | MEQAIINDEREYLRHFWHPVCTVTELEKAHPSSLGPLAVKLLNEQLVVAKLGDEYVAMRD RCAHRSAKLSLGTVSGNRLQCPYHGWQYDTHGACQLVPACPNSPIPNKAKVDRFDCEERY GLIWIRLDSSFDCTEIPYFSAANDPRLRIVIQEPYWWDATAERRWENFTDFSHFAFIHPG TLFDPNNAEPPIVPMDRFNGQFRFVYDTPEDMAVPNQAPIGSFSYTCSMPFAINLEVSKY SSSSLHVLFNVSCPVDSHTTKNFLIFAREQSDDSDYLHIAFNDLVFAEDKPVIESQWPKD APADEVSVVADKVSIQYRKWLRELKEAHKEGSQAFRSALLDPVIESDRSYI |
| methylxanthine N3-demethylase(K21723) | MKEQLKPLLEDKTYLRHFWHPVCTLNEFERANASGHGPMGVTLLGEKLVLARLNSKIIAA ADRCAHRSAQLSIGRVCSNAGKDYLECPYHGWRYDEAGACQLIPACPDKSISPRAKISSF DCEVKYDIVWVRLDNSFDCTQIPYLSDFDNPDMQVIVADSYIWETVAERRWENFTDFSHF AFVHPGTLYDPFFASHPTVYVNRVDGELQFKLAPPREMKGIPPEAPMGDFTYRCTMPYSV NLEIKLWKDDSRFVLWTTASPVDNKSCRNFMIIVREKDNQPDHMHLAFQKRVLDEDQPVI ESQWPLEIQTSEVSVATDKISVQFRKWHKELSLSAVEGREAFRDSVLTNVIEEEQ |
| 7-methylxanthine demethylase(K21724) | MSTDQVIFNDWHPVAALEDVSLDKRYRCRLLGRTVSYVKTSDAVNAHWEESADGIKTIRA KEIYGLLWLSFADKPSEMFDIAEFKEPDRRIVSAGSVRVNVSGLRAIENFLDMAHFPFVH TDILGAEPLTEVGPYNVNYVETVDEIFATECKFPQPKGSATAVEPIDMQYIYRITRPYSA ILYKTCPPEPHRWDALGLFIQPVDEDWCIAHTIMCYVDDVNSDQQLRHFQQTIFGQDLMI LINQVPKRLPLAASRESPVRADVLATAYRRWLREKGVQYGALRD |
| cytochrome P450 family 1 subfamily A2(K07409) | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN |
| arylamine N-acetyltransferase(K00622) | MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVV RRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYI VDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDL LEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLT HRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI |
| cytochrome P450 family 2 subfamily A6(K17683) | MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF ATIPRNYTMSFLPR |
| xanthine dehydrogenase/oxidase(K00106) | MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDR LQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI VMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCC MNQKKDHSVSLSPSLFKPEEFTPLDPTQEPIFPPELLRLKDTPRKQLRFEGERVTWIQAS TLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFG AACPLSIVEKTLVDAVAKLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISD LNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSA FKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKLWKE ELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQENLEDKCGKLD PTFASATLLFQKDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRY ENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICNDETVFAKDK VTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDL KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKM LGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGR HPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGR LCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL EGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGA LLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAA SVSADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLG YSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAF VQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAV GEPPLFLAASIFFAIKDAIRAARAQHTGNNVKELFRLDSPATPEKIRNACVDKFTTLCVT GVPENCKPWSVRV |
| caffeine dehydrogenase subunit alpha(K21673) | MFADINKGDAFGTWVGKSVPRREDADILAGRAEYIADIKLPGMLEAAFLRSPFAHARIVS IDVSQALALPGVYDVMVGADIPDYVKPLPLMITYQNHRETPTSPLARDIVRYAGEPVAVV AAINRYVAEDALELIVVKYEELPVVASIDASLAVDGPRLYEGWPDNVVAKVSSEIGDVDA AMASADLVFEERFEIQRCHPAPLETRGFIAQWDFKGENLNVWNGTQIINQCRDFMSEVLD IPASKIRIRSPRLGGGFGAKFHFYVEEPAIVLLAKRVKAPVRWIEDRLEAFSATVHAREQ VIDVKLCAMNDGRITGIVADIKGDLGASHHTMSMGPVWLTSVMMTGVYLIPNARSVAKAI VTNKPPSGSYRGWGQPQANFAVERMVDLLAHKLQLDPAAVRRINYVPEARMPYTGLAHTF DSGRYEVLHDRALKTFGYEAWLERQAAAQAQGRRIGIGMSFYAEVSAHGPSRFLNYVGGR QGGYDIARIRMDTTGDVYVYTGLCDMGQGVTNSLAQIAADALGLNPDDVTVMTGDTALNP YTGWGTGASRSITIGGPAVMRAATRLREKILSIARHWLQADPDTLVLANRGVMVRDDPGR YVSFASIGRAAYCQIIELPEDVEPGLEAVGVFDTVQLAWPYGMNLVAVEVDEDTGAVSFL DCMLVHDMGTIVNPMIVDGQLHGGIAQGIAQALYEELRYDENGQLGTGSFADFLMPTASE IPNMRFDHMVTESPLIPGGMKGVGEGGTIGTPAAVVNAIENALRPITNSKLNRTPVTPDR ILTAISAGACA |
| caffeine dehydrogenase subunit beta(K21674) | MKPTAFDYIRPTSLPEALAILAEHSDDVAILAGGQSLMPLLNFRMSRPALVLDINDISEL QQVRCENDTLYVGSMVRHCRVEQEEIFRSTIPLMSEAMTSVAHIQIKTRGTLGGNLCNAH PASEMPAVITALGASMVCKSEKRGERVLTPEEFFEGALQNGLQSDELLCEIRIPVPSQYV GWAFEEVARRHGDFAQCGAAVLIGAEDRKIDYARIALCSIGETPIRFHALEQWLIGRPVG NDLPADVKLHCREILDVAEDSTMTAENRAKLASAVTSRAIARAADRIVHLDVKRG |
| caffeine dehydrogenase subunit gamma(K21675) | MSSHVISLTVNGQAIERKVDSRTLLADFLRDELRLTGTHVGCEHGVCGACTIQFDGEPAR SCLMLAVQAEGHSIRTVEALAVDGCLGALQQAFHEKHGLQCGFCTPGLLMTLDYALTADL HIDFSSDKEIRELISGNLCRCTGYQNIINAIKSVSPTTEIAKSEELV |
| urate oxidase(K00365) | MSAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDS IKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHS FIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILS TDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQIL ARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRSSLKS KL |
| urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase(K16838) | MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSDLHRKMTGIVKAADRET QLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFLMLNEHYYDRFGFPFILAV KGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLADIITEKGETQMKRTMSYGKG NVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCEIGGEAFLPSFTDGDNTLVVATD SMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHMDTITLTGEDIPFEAMPAYEEKELS TSRLVFRRSRNERSRSVLKAERSGNTITITEQYSEIMDLQLVKVSGNSFVGFIRDEYTTL PEDGNRPLFVYLNISWQYENTNDSYASDPARYVAAEQVRDLASTVFHELETPSIQNLIYH IGCRILARFPQLTDVSFQSQNHTWDTVVEEIPGSKGKVYTEPRPPYGFQHFTVTREDAEK EKQKAAEKCRSLKA |
| 1,3,7-trimethyluric acid 5-monooxygenase(K00492) | MSRPLRVTIIGAGIGGLSAAVALRKIGADVTVVERAPELRAAGAGICMWPNGAQALHALG IANPLEMVSPILHRVCYRDQHGRVIREMSIDKLTELVGQRPFPLARSDLQAALLSRLDPA LVRLGGACVSVEQDANGVRAVLDDGTEIASDLLVGADGIRSVVRNHVTGGTDRLRYHYTT WLGLVSFGLNLTPPGTFTFHVQDSKRVGLLNVGDDRLYFFFDAVPSGEANPDGVRAELRH HFDGWCSEVTTLVEALDEAKTNRLPVHDLDPLASFVNGRIVLIGDAAHATTPTLGQGGAL AMEDSLVLARHLAESTDYGSALASYDNERLMRTRQVVLASRARTAATLGIDNTSAQTWQK QLTDDASQDFLEQLVDIHRAGPLAAWPHDRQEGVAT |